
Modular precision multi-payload targeting across solid and liquid tumors
Our lead candidate is an EpCAM-targeted RNA nanoparticle for metastatic colorectal cancer with a validated oncology payload.

Our lead candidate is an EpCAM-targeted RNA nanoparticle for metastatic colorectal cancer with a validated oncology payload.
RNA Nanobiotics has emerged from stealth following $50+ million in deployed non-dilutive funding and seed investment, establishing a proprietary RNA nanostructure platform supported by 200+ peer-reviewed publications and secured through an exclusive worldwide license to Dr. Peixuan Guo’s 3WJ and 4WJ RNA nanotechnology patents. The company is now advancing its lead programs toward clinical development.
Wang H. et al. Chemical Engineering Journal 526 (2025)

RNA NanoBiotics is a biotechnology company developing targeted RNA nanoparticle therapeutics for difficult-to-treat cancers. Our lead program is designed to deliver an approved chemotherapeutic payload specifically to metastatic colorectal cancer cells, reducing systemic toxicity and accelerating clinical entry through a 505(b)(2) strategy. Supported by peer-reviewed science and issued patents, the platform is engineered for adaptability across additional oncology targets following initial clinical validation.
RNA NanoBiotics is advancing a focused oncology pipeline built around targeted RNA nanoparticle therapeutics, beginning with a clearly defined lead program intended to validate the platform in the clinic.
The lead program is an EpCAM-targeted RNA nanoparticle for metastatic colorectal cancer, designed to selectively deliver a validated oncology payload to tumor cells.
RNA nanoparticles are engineered with molecular targeting elements to preferentially accumulate in tumor tissue, improving therapeutic index while reducing systemic exposure and off-target toxicity.
Clinical development is structured around a 505(b)(2) regulatory pathway, leveraging approved oncology payloads to reduce development risk, time, and capital requirements on the path to first-in-human studies.
Following clinical validation of the lead program, the modular RNA nanoparticle platform enables efficient expansion to additional oncology targets and combination payloads using the same core delivery architecture.
The RNA nanoparticle platform has undergone independent manufacturing and CMC validation, including external evaluation by Eli Lilly and Company, demonstrating reproducible assembly, scalability, and suitability for clinical-grade production.

President, CEO and Chairman
25+ years in Executive Management, strategy, corporate and business development, and investments. President of Wharton Alumni Angels
Wharton

Chief Technology Officer
Technology, Operations and Strategy Executive, Niche in Translational Research and Clinical & Commercial Strategy, Serial entrepreneur in therapeutics and med-tech, Led >20 early-stage clinical programs, Managing Director of Life Sciences, Wharton Alumni Angels, VP BoD Penn Club of Boston; Co-Chair of Women in Lead
Chief Technology Officer
Technology, Operations and Strategy Executive, Niche in Translational Research and Clinical & Commercial Strategy, Serial entrepreneur in therapeutics and med-tech, Led >20 early-stage clinical programs, Managing Director of Life Sciences, Wharton Alumni Angels, VP BoD Penn Club of Boston; Co-Chair of Women in Leadership fostering development in STEM and finance
Penn

Chairman Scientific Advisory Board
Professor, Sylvan G. Frank Endowed Chair
Pharmaceutics and Pharmacology, Ohio State University; 2021 Innovator Of The Year Ohio State University; Fellow of the National Academy of Inventors (NAI); Director of Center for RNA Nanobiotechnology and Nanomedicine; President of International Society of RNA Nanot
Chairman Scientific Advisory Board
Professor, Sylvan G. Frank Endowed Chair
Pharmaceutics and Pharmacology, Ohio State University; 2021 Innovator Of The Year Ohio State University; Fellow of the National Academy of Inventors (NAI); Director of Center for RNA Nanobiotechnology and Nanomedicine; President of International Society of RNA Nanotechnology and Nanomedicine; International Society of RNA Nanotechnology and Nanomedicine

Board Member
Pioneered strategic initiatives in drug development, leading to significant advancements in cancer treatment and patient care. Spearheaded the development and commercialization of groundbreaking therapies, overseeing research, business development, and licensing. Expert in clinical trial design.
Wharton

Board Member
Executive & Investor with 25+ years in healthcare and life sciences, experienced in equity investment, board governance, marketing, and business development; Board Member of Spectral AI (NASDAQ: MDAI), Arthrosi Therapeutics, Amberstone Biosciences, Basking Biosciences, HAYA Therapeutics, and the Science History Institute.
Wharton.
Aptamers are Chemical Antibodies!
Dr. Peixuan Guo: Ohio State University Innovator of the Year
Research Papers Published Independent of Company or OSU
Peixuan Guo publications https://rnanano.osu.edu/Guo/publications.html
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